Questions: Learning Objective: Can you compare and contrast the different signaling pathways? Question: Interpret the model and determine if the following statement is true or false. True or False: If cortisol levels are low, the production of CRH will be low. True False

Learning Objective: Can you compare and contrast the different signaling pathways? Question: Interpret the model and determine if the following statement is true or false. True or False: If cortisol levels are low, the production of CRH will be low. True False
Transcript text: Learning Objective: Can you compare and contrast the different signaling pathways? Question: Interpret the model and determine if the following statement is true or false. True or False: If cortisol levels are low, the production of CRH will be low. True False
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Solution

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Solution Steps

Step 1: Understanding the HPA Axis

The diagram illustrates the hypothalamic-pituitary-adrenal (HPA) axis. The hypothalamus releases corticotropin-releasing hormone (CRH), which stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH). ACTH then stimulates the adrenal gland to produce cortisol. Cortisol exerts negative feedback on both the hypothalamus and the anterior pituitary.

Step 2: Negative Feedback Mechanism

When cortisol levels are high, this negative feedback inhibits the release of CRH and ACTH, reducing further cortisol production. Conversely, when cortisol levels are low, the negative feedback is reduced, allowing for increased production of CRH and ACTH, ultimately leading to increased cortisol production.

Step 3: Evaluating the statement

The statement "If cortisol levels are low, the production of CRH will be low" is False. Low cortisol levels diminish the negative feedback on the hypothalamus, leading to _increased_ CRH production to stimulate cortisol production and bring levels back to normal.

Final Answer

\\(\boxed{\text{False}}\\)

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