The point-slope form of a line's equation is given by:
\[ y - y_1 = m(x - x_1) \]
where \( m \) is the slope, and \((x_1, y_1)\) is a point on the line.
We are given the slope \( m = -\frac{3}{8} \) and the point \((-10, -2)\). Substitute these values into the point-slope form equation:
\[ y - (-2) = -\frac{3}{8}(x - (-10)) \]
Simplify the equation by removing the double negatives:
\[ y + 2 = -\frac{3}{8}(x + 10) \]
The equation of the line in point-slope form is:
\[ \boxed{y + 2 = -\frac{3}{8}(x + 10)} \]
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