Questions: For shop spills larger than 12 gallons or 100 pounds, contact the City where your shop is located, National Response Center, Centers for Disease Control and Prevention (CDC), County where your shop is located.

The answer is the second one: National Response Center.

Explanation for each option:

1. City where your shop is located: While local authorities may need to be informed about certain incidents, the National Response Center is the primary federal point of contact for reporting oil and chemical spills.

2. National Response Center: This is the correct answer. The National Response Center (NRC) is the federal point of contact for reporting all oil, chemical, radiological, biological, and etiological discharges into the environment anywhere in the United States and its territories.

3. Centers for Disease Control and Prevention (CDC): The CDC is primarily focused on public health and disease prevention, not environmental spills.

4. County where your shop is located: Similar to the city option, while local authorities might be involved, the National Response Center is the appropriate federal contact for such spills.

In summary, for shop spills larger than 12 gallons or 100 pounds, the National Response Center should be contacted.