Questions: According to the video clip, "James Monroe: Major Events," one commentator noted that was "... a nest of pirates and outlaws and there are Indian tribes who live there, who are certainly not under the control of the Spanish government."

To answer this question, we need to identify the location being described in the video clip "James Monroe: Major Events." The description provided in the question suggests a place that was known for lawlessness and lack of control by the Spanish government, involving pirates, outlaws, and Indian tribes.

The answer is Florida.

During the early 19th century, Florida was indeed considered a problematic region for the United States. It was under Spanish control, but the Spanish government had little effective authority over the area. This lack of control allowed it to become a haven for pirates, outlaws, and various Native American tribes, such as the Seminoles, who were not under Spanish jurisdiction. This situation eventually led to the First Seminole War and the subsequent Adams-Onís Treaty, through which the United States acquired Florida from Spain in 1819.