To simplify the given expression, we need to follow these steps:
We start with the expression
\[ \left(\frac{-2 m^{-2} n^{3} p^{2}}{4 m^{-3} n^{-2} p^{-1}}\right)^{-3} \]
First, we simplify the fraction inside the parentheses. The coefficients give us
\[ \frac{-2}{4} = -\frac{1}{2} \]
Next, we simplify the variables by applying the laws of exponents:
\[ m^{-2} \div m^{-3} = m^{-2 - (-3)} = m^{1} \]
\[ n^{3} \div n^{-2} = n^{3 - (-2)} = n^{5} \]
\[ p^{2} \div p^{-1} = p^{2 - (-1)} = p^{3} \]
Thus, the simplified fraction becomes
\[ -\frac{1}{2} m^{1} n^{5} p^{3} = -\frac{m n^{5} p^{3}}{2} \]
Now we apply the negative exponent of \(-3\):
\[ \left(-\frac{m n^{5} p^{3}}{2}\right)^{-3} = \left(-1\right)^{-3} \cdot \left(\frac{m n^{5} p^{3}}{2}\right)^{-3} \]
Calculating \((-1)^{-3}\) gives us \(-1\). For the fraction, we have:
\[ \left(\frac{1}{2}\right)^{-3} = 2^{3} = 8 \]
And for the variables:
\[ (m n^{5} p^{3})^{-3} = m^{-3} n^{-15} p^{-9} \]
Combining these results, we get:
\[ -1 \cdot 8 \cdot m^{-3} n^{-15} p^{-9} = -\frac{8}{m^{3} n^{15} p^{9}} \]
Thus, the final simplified expression is
\[ \boxed{-\frac{8}{m^{3} n^{15} p^{9}}} \]
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