Questions: Which of the following stimulates Na+ reabsorption in the kidney?
Renin
Angiotensin I
Angiotensin II
Aldosterone
Transcript text: Which of the following stimulates $\mathrm{Na}^{+}$ reabsorption in the kidney?
Renin
Angiotensin I
Angiotensin II
Aldosterone
Solution
The answer is: Aldosterone.
Explanation for each option:
Renin: Renin is an enzyme secreted by the kidneys that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS). It initiates the conversion of angiotensinogen to angiotensin I, but it does not directly stimulate sodium reabsorption.
Angiotensin I: This is a precursor molecule that is converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE). Angiotensin I itself does not directly stimulate sodium reabsorption.
Angiotensin II: This peptide hormone does stimulate sodium reabsorption indirectly by promoting the release of aldosterone and by causing vasoconstriction, which increases blood pressure. However, it is not the primary hormone responsible for directly stimulating sodium reabsorption in the kidney.
Aldosterone: This is a steroid hormone produced by the adrenal cortex. It directly stimulates sodium reabsorption in the distal tubules and collecting ducts of the nephron in the kidney. It increases the expression of sodium channels and sodium-potassium pumps, leading to increased sodium reabsorption and potassium excretion.
In summary, while angiotensin II plays a role in the process, aldosterone is the hormone that directly stimulates sodium reabsorption in the kidney.