Questions: Which of the following indicates a client has diabetes? Oral glucose tolerance test of 250 mg / dL on at least two separate occasions Fasting blood glucose of 115 mg / dL on at least two separate occasions Family history of early-onset diabetes Family history of neuropathy in the feet.

The answer is the first one: Oral glucose tolerance test of \(250 \, \text{mg/dL}\) on at least two separate occasions.

Explanation for each option:

1. Oral glucose tolerance test of \(250 \, \text{mg/dL}\) on at least two separate occasions: This is a clear indicator of diabetes. According to the American Diabetes Association, a 2-hour plasma glucose level of \(200 \, \text{mg/dL}\) or higher during an oral glucose tolerance test is diagnostic for diabetes. Therefore, \(250 \, \text{mg/dL}\) on two separate occasions confirms the diagnosis.

2. Fasting blood glucose of \(115 \, \text{mg/dL}\) on at least two separate occasions: This level is considered to be in the range of impaired fasting glucose (pre-diabetes), not diabetes. A fasting blood glucose level of \(126 \, \text{mg/dL}\) or higher is required for a diabetes diagnosis.

3. Family history of early-onset diabetes: While a family history can increase the risk of developing diabetes, it is not a diagnostic criterion. It indicates a predisposition but does not confirm the presence of the disease.

4. Family history of neuropathy in the feet: Similar to the previous option, a family history of neuropathy can be associated with diabetes complications but is not a diagnostic criterion for diabetes itself.

In summary, the oral glucose tolerance test result of \(250 \, \text{mg/dL}\) on at least two separate occasions is the definitive indicator of diabetes among the options provided.