Questions: What is unique about the Primase compared to other DNA Polymerases? A. It extends in the 5'to 3' direction B. It uses nucleotide triphosphates C. It does not require a pre-existing 3,'-OH

What is unique about the Primase compared to other DNA Polymerases?
A. It extends in the 5'to 3' direction
B. It uses nucleotide triphosphates
C. It does not require a pre-existing 3,'-OH
Transcript text: What is unique about the Primase compared to other DNA Polymerases? A. It extends in the 5'to 3' direction B. It uses nucleotide triphosphates C. It does not require a pre-existing 3,'-OH
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Solution

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Solution Steps

Step 1: Understanding the Role of Primase

Primase is an enzyme that synthesizes short RNA primers during DNA replication. These primers are necessary for DNA polymerases to begin synthesis of the new DNA strand.

Step 2: Comparing Primase to Other DNA Polymerases

Other DNA polymerases require a pre-existing 3'-OH group to add nucleotides. They cannot initiate synthesis on their own and need a primer to start the process.

Step 3: Identifying the Unique Feature of Primase

Primase is unique because it can synthesize RNA primers de novo, meaning it does not require a pre-existing 3'-OH group to start the synthesis. This is in contrast to other DNA polymerases.

Final Answer

C. It does not require a pre-existing 3'-OH

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