Questions: The effects of competitive inhibitors can be diluted out by substrate but those of uncompetitive and mixed inhibitors cannot.

The answer is True.

Explanation: Competitive inhibitors bind to the active site of an enzyme, competing directly with the substrate. As the concentration of the substrate increases, it can outcompete the inhibitor for the active site, thereby diluting the effect of the competitive inhibitor.

Uncompetitive inhibitors, on the other hand, bind only to the enzyme-substrate complex, not to the free enzyme. Increasing the substrate concentration does not affect the binding of uncompetitive inhibitors because they only bind after the substrate has already bound to the enzyme.

Mixed inhibitors can bind to both the free enzyme and the enzyme-substrate complex, but their effects are not simply diluted out by increasing substrate concentration. The presence of the inhibitor affects both the binding of the substrate and the catalytic activity of the enzyme, making it impossible to completely overcome the inhibition by merely increasing the substrate concentration.

Therefore, the statement that the effects of competitive inhibitors can be diluted out by substrate but those of uncompetitive and mixed inhibitors cannot is true.