Questions: Answer Bank Put it in order RNA is replaced with DNA and lagging strands are joined. Each genomic origin of replication assembles a prereplication complex. RNA primers are added to provide a 3' end for elongation. Active telomerase can extend the lost telomere region. 5' to 3' synthesis of the leading and lagging strands is carried out by DNA polymerase. The initiation complex creates an active replication fork as helicase unwinds DNA.

To put the steps of DNA replication in order, we need to follow the sequence of events that occur during the process. Here is the correct order:

1. Each genomic origin of replication assembles a prereplication complex.
   This is the initial step where the replication machinery is assembled at the origin of replication.

2. The initiation complex creates an active replication fork as helicase unwinds DNA.
   Helicase unwinds the DNA double helix, creating a replication fork where the DNA strands are separated.

3. RNA primers are added to provide a $3^{\prime}$ end for elongation.
   RNA primers are synthesized by primase to provide a starting point for DNA polymerase to begin synthesis.

4. $5^{\prime}$ to $3^{\prime}$ synthesis of the leading and lagging strands is carried out by DNA polymerase.
   DNA polymerase synthesizes the new DNA strands in the 5' to 3' direction, with continuous synthesis on the leading strand and discontinuous synthesis on the lagging strand.

5. RNA is replaced with DNA and lagging strands are joined.
   The RNA primers are removed and replaced with DNA, and the Okazaki fragments on the lagging strand are joined by DNA ligase.

6. Active telomerase can extend the lost telomere region.
   Telomerase extends the telomeres at the ends of linear chromosomes to prevent loss of genetic information after replication.

In summary, the correct order of events in DNA replication is: assembly of the prereplication complex, creation of the replication fork, addition of RNA primers, synthesis of DNA strands, replacement of RNA with DNA and joining of fragments, and extension of telomeres by telomerase.