Questions: Select all that apply Which of the following statements correctly describe leukotrienes? Select all that apply. A key step in the synthesis of leukotriene C4 is opening of the epoxide ring of leukotriene A4 with a sulfur nucleophile. Leukotrienes contribute to the asthmatic response. Leukotrienes are synthesized in the cell from glycolic acid.

The correct statements that describe leukotrienes are:

1. A key step in the synthesis of leukotriene \(C_{4}\) is opening of the epoxide ring of leukotriene \(A_{4}\) with a sulfur nucleophile.

   • This statement is correct. Leukotriene \(C_{4}\) is synthesized from leukotriene \(A_{4}\) through the addition of glutathione, which acts as a sulfur nucleophile, opening the epoxide ring.

2. Leukotrienes contribute to the asthmatic response.

   • This statement is correct. Leukotrienes are inflammatory mediators that play a significant role in the pathophysiology of asthma by causing bronchoconstriction, increased vascular permeability, and attracting immune cells to the site of inflammation.

3. Leukotrienes are synthesized in the cell from glycolic acid.

   • This statement is incorrect. Leukotrienes are not synthesized from glycolic acid. They are derived from arachidonic acid, a polyunsaturated fatty acid, through the lipoxygenase pathway.

In summary, the correct statements are the first two: the synthesis of leukotriene \(C_{4}\) involves the opening of the epoxide ring of leukotriene \(A_{4}\) with a sulfur nucleophile, and leukotrienes contribute to the asthmatic response.