The given expression is:
\[ \frac{2 m^{9} n^{4}}{-4 m^{-3} n^{-2}} \]
First, simplify the coefficients:
\[ \frac{2}{-4} = -\frac{1}{2} \]
Next, simplify the powers of \(m\) and \(n\) using the laws of exponents:
\[ m^{9} \div m^{-3} = m^{9 - (-3)} = m^{9 + 3} = m^{12} \]
\[ n^{4} \div n^{-2} = n^{4 - (-2)} = n^{4 + 2} = n^{6} \]
Combine the simplified coefficient and the simplified powers of \(m\) and \(n\):
\[ -\frac{1}{2} \cdot m^{12} \cdot n^{6} = -\frac{m^{12} n^{6}}{2} \]
The simplest form of the given expression is:
\[ \boxed{-\frac{m^{12} n^{6}}{2}} \]
Thus, the answer is the second option:
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