Questions: A client with cirrhosis is complaining of severe pruritus related to the accumulation of bile salts. What can be prescribed for the client to relieve the itching? A. Cholestyramine B. Kanamycin C. Lactulose D. Cyclosporine

The answer is the first one (A): Cholestyramine.

Explanation for each option: A. Cholestyramine - Correct. Cholestyramine is a bile acid sequestrant that binds bile salts in the intestine, preventing their reabsorption and thereby reducing the pruritus associated with bile salt accumulation in patients with cirrhosis. B. Kanamycin - Incorrect. Kanamycin is an antibiotic and does not have any effect on bile salts or pruritus. C. Lactulose - Incorrect. Lactulose is used to treat hepatic encephalopathy by reducing ammonia levels in the blood, but it does not address pruritus caused by bile salts. D. Cyclosporine - Incorrect. Cyclosporine is an immunosuppressant used in transplant patients and certain autoimmune conditions, and it does not relieve pruritus related to bile salts.

Summary: Cholestyramine is the appropriate medication to prescribe for a client with cirrhosis experiencing severe pruritus due to the accumulation of bile salts.