Questions: Question 5 A professor at Big State University proposes to study attitudes about obesity in Chile by giving subjects in Chile surveys to complete. Which is a question that the Big State University IRB should ask the researcher in order to determine if this study should be reviewed by a local Chilean IRB or ethics committee, as well as the Big State University IRB? Is the survey more than minimal risk? Will the researchers have collaborators at the research site abroad? Does the professor speak Spanish fluently? Does the potential subject population include children?

To determine if the study should be reviewed by a local Chilean IRB or ethics committee, as well as the Big State University IRB, the Big State University IRB should consider the following question:

• Will the researchers have collaborators at the research site abroad?

While assessing the risk level of the survey is important for ethical review, it does not directly address the need for local IRB involvement. The risk level is a factor for any IRB review but does not specifically determine the necessity of involving a local IRB.

This question is crucial because having local collaborators can necessitate a review by a local IRB or ethics committee. Local collaborators may have insights into cultural sensitivities and ethical standards that are specific to the region, which can influence the ethical considerations of the study.

While language proficiency is important for effective communication and data collection, it does not directly impact the need for local IRB review. However, it may affect the quality and ethical conduct of the research.

Involving children in research typically requires additional ethical considerations and protections, but it does not specifically address the need for local IRB involvement unless local regulations or cultural norms dictate such a requirement.