Questions: Large, negatively charged proteins inside the cell cannot readily diffuse across the neuron membrane.

The answer is: cannot

Explanation: Large, negatively charged proteins inside the cell cannot readily diffuse across the neuron membrane. This is because the neuron membrane is selectively permeable and typically impermeable to large molecules and charged particles without the assistance of specific transport mechanisms. The lipid bilayer of the membrane acts as a barrier to such large and charged entities, preventing their free diffusion.