Questions: Wilson's disease Masklike facies Elevated unconjugated bilirubin Kayser-Fleischer rings of the cornea Low ceruloplasmin levels High urinary copper Copper accumulation

Wilson's disease Masklike facies Elevated unconjugated bilirubin Kayser-Fleischer rings of the cornea Low ceruloplasmin levels High urinary copper Copper accumulation
Transcript text: Wilson's disease Masklike facies Elevated unconjugated bilirubin Kayser-Fleischer rings of the cornea Low ceruloplasmin levels High urinary copper Copper accumulation
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Solution

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The correct characteristics for Wilson's disease are:

  • Kayser-Fleischer rings of the cornea
  • Low ceruloplasmin levels
  • High urinary copper
  • Copper accumulation

Explanation:

  1. Kayser-Fleischer rings of the cornea: These are deposits of copper in the cornea and are a classic sign of Wilson's disease.

  2. Low ceruloplasmin levels: Ceruloplasmin is a protein that binds copper in the blood. In Wilson's disease, ceruloplasmin levels are typically low.

  3. High urinary copper: Due to impaired copper metabolism, individuals with Wilson's disease often excrete high levels of copper in their urine.

  4. Copper accumulation: Wilson's disease is characterized by the accumulation of copper in various body tissues, particularly the liver and brain.

The other characteristics listed do not apply to Wilson's disease:

  • Masklike facies: This is more commonly associated with Parkinson's disease or other neurological disorders.

  • Positive HCV RNA assay: This is indicative of Hepatitis C infection, not Wilson's disease.

  • Elevated unconjugated bilirubin: This is typically associated with conditions like Gilbert's syndrome or hemolytic anemia, not Wilson's disease.

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