To simplify the given expression, we need to follow these steps:
We start with the expression \( (75xy)\left(5x^{2}y^{-5}\right)^{2} \). First, we distribute the exponent in the second term:
\[ \left(5x^{2}y^{-5}\right)^{2} = 5^{2} \cdot (x^{2})^{2} \cdot (y^{-5})^{2} = 25 \cdot x^{4} \cdot y^{-10} \]
Next, we multiply the first term \( 75xy \) by the result from Step 1:
\[ (75xy) \cdot (25x^{4}y^{-10}) = 75 \cdot 25 \cdot x^{1} \cdot x^{4} \cdot y^{1} \cdot y^{-10} \]
Now, we combine the coefficients and the exponents of like bases:
Thus, the expression simplifies to:
\[ 1875 \cdot x^{5} \cdot y^{-9} \]
The final simplified expression is
\[ \boxed{1875x^{5}y^{-9}} \]
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