Questions: Which statement about enzymes is FALSE? Enzymes may use coenzymes derived from vitamins or cofactors from metallic elements. Most enzymes can catalyze millions of reactions per minute. Enzymes may be damaged by high temperature. The shape of the active site on an enzyme is not influenced by the substrate.

The answer is the fourth one: The shape of the active site on an enzyme is not influenced by the substrate.

Explanation for each option:

1. Enzymes may use coenzymes derived from vitamins or cofactors from metallic elements.
   This statement is true. Enzymes often require additional non-protein molecules called coenzymes or cofactors to assist in catalyzing reactions. Coenzymes are often derived from vitamins, and cofactors can include metallic elements.

2. Most enzymes can catalyze millions of reactions per minute.
   This statement is true. Enzymes are highly efficient catalysts and can facilitate a large number of reactions in a very short time, often catalyzing millions of reactions per minute.

3. Enzymes may be damaged by high temperature.
   This statement is true. High temperatures can denature enzymes, altering their structure and rendering them inactive.

4. The shape of the active site on an enzyme is not influenced by the substrate.
   This statement is false. The shape of the active site is indeed influenced by the substrate. This is part of the induced fit model, where the enzyme changes shape slightly to accommodate the substrate, enhancing the enzyme's ability to catalyze the reaction.

In summary, the false statement is that the shape of the active site on an enzyme is not influenced by the substrate.