Questions: Sickle cell disease impact on circulatory system (Keyboard Navigable Alternate Version) Complete the following paragraph to explain the physiological impact of sickle-cell disease on the circulatory system. a. The structure of (Click to select) ; suits its function in gas exchange. Because red blood cells are responsible for delivering hemoglobin and oxygen to every cell of the body, any change in the structure of hemoglobin will change the (Click to select) of the red blood cell. b. With sickle cell disease, the hemoglobin in red blood cells is (Click to select) . This in turn changes the shape and damages the (Click to select) , the major type of cell in the circulatory system. c. Sickle red blood cells (Click to select) : together, blocking small blood vessels and causing painful and damaging problems. d. Sickle cell disease also prevents the hemoglobin in red blood cells from carrying (Click to select) :to all parts of the body. As oxygen concentration of the body drops in the individual, a condition called (Click to select) develops.

To complete the paragraph explaining the physiological impact of sickle-cell disease on the circulatory system, let's fill in the blanks with appropriate terms:

a. The structure of red blood cells suits its function in gas exchange. Because red blood cells are responsible for delivering hemoglobin and oxygen to every cell of the body, any change in the structure of hemoglobin will change the shape of the red blood cell.

b. With sickle cell disease, the hemoglobin in red blood cells is abnormal. This in turn changes the shape and damages the red blood cells, the major type of cell in the circulatory system.

c. Sickle red blood cells stick together, blocking small blood vessels and causing painful and damaging problems.

d. Sickle cell disease also prevents the hemoglobin in red blood cells from carrying oxygen to all parts of the body. As oxygen concentration of the body drops in the individual, a condition called anemia develops.

Summary: Sickle-cell disease affects the circulatory system by altering the structure of hemoglobin, which changes the shape of red blood cells. These sickle-shaped cells can block blood vessels, leading to pain and damage, and they are less effective at carrying oxygen, resulting in anemia.