The answer is the last one (or C): damaged cells release molecules that increase blood flow.
Explanation for each option:
A. A pathogen first invades host tissue: This is not the direct trigger for the inflammatory response. While the presence of a pathogen can lead to inflammation, the immediate trigger is the release of signaling molecules by damaged cells.
B. Phagocytes engulf pathogens: This is a part of the immune response, but it is not the initial trigger for inflammation. Phagocytosis occurs after the inflammatory response has been initiated.
D. Clotting reactions seal off the infected area: Clotting is a response to injury and can occur during inflammation, but it is not the trigger for the inflammatory response.
C. Damaged cells release molecules that increase blood flow: This is the correct answer. When cells are damaged, they release signaling molecules such as histamines and cytokines, which increase blood flow to the affected area and trigger the inflammatory response.
Summary:
The inflammatory response is triggered when damaged cells release molecules that increase blood flow.