Questions: Question 1 (Mandatory) (2 points) The safety margin for a particular drug is based on the idea that toxic doses will typically be larger than therapeutic doses. most drugs cause toxicity problems only when combined with other drugs. we need to determine an LD50 using human volunteers. we should only prescribe drugs that are not toxic even at high doses.

The answer is the first one: the safety margin for a particular drug is based on the idea that toxic doses will typically be larger than therapeutic doses.

Explanation for each option:

1. Toxic doses will typically be larger than therapeutic doses.

   • This is correct. The safety margin of a drug is the range between the dose that produces the desired therapeutic effect and the dose that produces toxic effects. A larger safety margin means that the toxic dose is significantly higher than the therapeutic dose, indicating a safer drug.

2. Most drugs cause toxicity problems only when combined with other drugs.

   • This is incorrect. While drug interactions can indeed cause toxicity, the safety margin concept is primarily concerned with the difference between therapeutic and toxic doses of a single drug.

3. We need to determine an LD50 using human volunteers.

   • This is incorrect. LD50 (lethal dose for 50% of the population) is typically determined using animal studies, not human volunteers, due to ethical concerns.

4. We should only prescribe drugs that are not toxic even at high doses.

   • This is incorrect. Many effective drugs can be toxic at high doses. The key is to prescribe them within the therapeutic range, where they are effective without being toxic.

Summary: The safety margin for a particular drug is based on the idea that toxic doses will typically be larger than therapeutic doses, ensuring that there is a buffer zone between the effective dose and the harmful dose.