Questions: A 35-year-old woman who is a non-smoker has recently been diagnosed with emphysema. Genetic testing shows that she is homozygous for the Z allele of alphal antitrypsin. In addition to the damage to her lungs, this mutation of alpha 1 antitrypsin will cause damage to her: Answers: A - E A Heart. B Kidneys. C Brain. D Liver. E Small intestine.

The answer is D: Liver.

Explanation for each option:

A. Heart: Alpha-1 antitrypsin deficiency primarily affects the lungs and liver. There is no direct association with heart damage due to this genetic condition.

B. Kidneys: While alpha-1 antitrypsin deficiency can have systemic effects, the kidneys are not typically affected by this condition.

C. Brain: There is no known direct impact of alpha-1 antitrypsin deficiency on the brain.

D. Liver: Correct. Individuals who are homozygous for the Z allele of alpha-1 antitrypsin are at risk for liver damage. This is because the abnormal protein can accumulate in the liver, leading to liver disease, including cirrhosis and liver failure.

E. Small intestine: The small intestine is not typically affected by alpha-1 antitrypsin deficiency.

In summary, the mutation of alpha-1 antitrypsin in this patient is likely to cause damage to her liver.