Questions: How does MOST thyroid hormone travel in the blood? a.) Free T3 b.) Free T4 c.) T3 and T4 bound to colloid d.) T3 and T4 bound to thyroxine-binding proteins (TBGs)

How does MOST thyroid hormone travel in the blood? a.) Free T3 b.) Free T4 c.) T3 and T4 bound to colloid d.) T3 and T4 bound to thyroxine-binding proteins (TBGs)
Transcript text: How does MOST thyroid hormone travel in the blood? a.) Free $T_{3}$ b.) Free $T_{4}$ c.) $T_{3}$ and $T_{4}$ bound to colloid d.) $T_{3}$ and $T_{4}$ bound to thyroxine-binding proteins (TBGs)
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Solution

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The answer is the fourth one (d): $T_{3}$ and $T_{4}$ bound to thyroxine-binding proteins (TBGs).

Explanation for each option: a.) Free $T_{3}$ - Incorrect. Only a small fraction of $T_{3}$ is free in the blood. Most of it is bound to proteins. b.) Free $T_{4}$ - Incorrect. Similar to $T_{3}$, only a small fraction of $T_{4}$ is free in the blood. The majority is bound to proteins. c.) $T_{3}$ and $T_{4}$ bound to colloid - Incorrect. Colloid is found within the thyroid gland, not in the bloodstream. d.) $T_{3}$ and $T_{4}$ bound to thyroxine-binding proteins (TBGs) - Correct. The majority of thyroid hormones ($T_{3}$ and $T_{4}$) in the blood are bound to thyroxine-binding globulin (TBG) and other proteins such as transthyretin and albumin.

Summary: Most thyroid hormone travels in the blood bound to thyroxine-binding proteins (TBGs).

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