Questions: Which example would likely result in new combinations of DNA in an individual's offspring? (1 point) Homologous chromosomes failing to separate during meiosis.

The answer is the first one: Homologous chromosomes failing to separate during meiosis.

Explanation for each option:

1. Homologous chromosomes failing to separate during meiosis: This process is known as nondisjunction and can lead to new combinations of DNA in an individual's offspring. During meiosis, homologous chromosomes are supposed to separate into different gametes. If they fail to do so, it can result in gametes with abnormal numbers of chromosomes, which can lead to genetic variation in the offspring.

2. A spontaneous mutation to the DNA in a lung cell during mitosis: This would not result in new combinations of DNA in an individual's offspring because it occurs in a somatic (body) cell, not in a germ cell (sperm or egg). Mutations in somatic cells do not get passed on to offspring.

3. Sister chromatids crossing over during mitosis in a heart cell: Crossing over typically occurs during meiosis, not mitosis. Even if it did occur during mitosis in a somatic cell, it would not affect the DNA combinations in the offspring because it would not be passed on to the next generation.

4. UV radiation causing a mutation in a skin cell resulting in melanoma: Similar to the second option, this mutation occurs in a somatic cell and would not be passed on to offspring. Therefore, it would not result in new combinations of DNA in the individual's offspring.

Summary: The most likely scenario to result in new combinations of DNA in an individual's offspring is homologous chromosomes failing to separate during meiosis.