To evaluate the integral over the region \( E \) enclosed by the given surfaces, we first convert the equations to cylindrical coordinates. The paraboloid \( z = 4 + x^2 + y^2 \) becomes \( z = 4 + r^2 \) in cylindrical coordinates, where \( r = \sqrt{x^2 + y^2} \). The cylinder \( x^2 + y^2 = 5 \) becomes \( r = \sqrt{5} \). The region \( E \) is bounded by \( 0 \leq r \leq \sqrt{5} \), \( 0 \leq \theta \leq 2\pi \), and \( 0 \leq z \leq 4 + r^2 \). The integral in cylindrical coordinates is then set up as \(\int_0^{2\pi} \int_0^{\sqrt{5}} \int_0^{4+r^2} e^z \, r \, dz \, dr \, d\theta\).
We need to evaluate the integral
\[
\iiint_{E} e^{z} \, dV
\]
over the region \( E \) enclosed by the paraboloid \( z = 4 + x^2 + y^2 \) and the cylinder \( x^2 + y^2 = 5 \). In cylindrical coordinates, the equations become \( z = 4 + r^2 \) and \( r = \sqrt{5} \). The limits for \( r \) are from \( 0 \) to \( \sqrt{5} \), for \( \theta \) from \( 0 \) to \( 2\pi \), and for \( z \) from \( 0 \) to \( 4 + r^2 \).
The integral can be expressed as:
\[
\int_0^{2\pi} \int_0^{\sqrt{5}} \int_0^{4+r^2} e^z \, r \, dz \, dr \, d\theta
\]
Evaluating the innermost integral with respect to \( z \):
\[
\int_0^{4+r^2} e^z \, dz = e^{4+r^2} - 1
\]
Thus, the integral becomes:
\[
\int_0^{2\pi} \int_0^{\sqrt{5}} (e^{4+r^2} - 1) r \, dr \, d\theta
\]
Now we evaluate the integral with respect to \( r \):
\[
\int_0^{\sqrt{5}} (e^{4+r^2} - 1) r \, dr
\]
This can be split into two parts:
- \( \int_0^{\sqrt{5}} e^{4+r^2} r \, dr \)
- \( \int_0^{\sqrt{5}} r \, dr \)
The first part evaluates to:
\[
\frac{1}{2} e^{4+r^2} \bigg|_0^{\sqrt{5}} = \frac{1}{2} (e^{9} - e^{4})
\]
The second part evaluates to:
\[
\frac{1}{2} r^2 \bigg|_0^{\sqrt{5}} = \frac{5}{2}
\]
Combining these results gives:
\[
\int_0^{\sqrt{5}} (e^{4+r^2} - 1) r \, dr = \frac{1}{2} (e^{9} - e^{4}) - \frac{5}{2}
\]
Finally, integrating with respect to \( \theta \):
\[
\int_0^{2\pi} \left( \frac{1}{2} (e^{9} - e^{4}) - \frac{5}{2} \right) d\theta = 2\pi \left( \frac{1}{2} (e^{9} - e^{4}) - \frac{5}{2} \right)
\]
The final result of the integral is:
\[
\boxed{2\pi \left( \frac{1}{2} (e^{9} - e^{4}) - \frac{5}{2} \right)}
\]