We start with the given differential equation:
\[
y' e^{y - 6x} = e^{x + 2y}
\]
Rearranging this, we can express \(y'\) as:
\[
y' = e^{x + 2y} e^{-(y - 6x)} = e^{7x + y}
\]
Next, we separate the variables \(y\) and \(x\):
\[
\frac{dy}{dx} = e^{7x + y}
\]
This can be rewritten as:
\[
\frac{dy}{e^y} = e^{7x} dx
\]
We integrate both sides:
\[
\int e^{-y} dy = \int e^{7x} dx
\]
The left side integrates to:
\[
-e^{-y}
\]
And the right side integrates to:
\[
\frac{1}{7} e^{7x} + C
\]
Setting the two integrals equal gives us:
\[
-e^{-y} = \frac{1}{7} e^{7x} + C
\]
Multiplying through by \(-1\) yields:
\[
e^{-y} = -\frac{1}{7} e^{7x} - C
\]
Taking the natural logarithm of both sides results in:
\[
-y = \ln\left(-\frac{1}{7} e^{7x} - C\right)
\]
Finally, we solve for \(y\):
\[
y = -\ln\left(-\frac{1}{7} e^{7x} - C\right)
\]
This expression represents the general solution of the differential equation.
\(\boxed{y = -\ln\left(-\frac{1}{7} e^{7x} - C\right)}\)