To simplify the given expression, we need to follow these steps:
The numerator of the given expression is: \[ 2 x^{-3} y^{-3} \]
The denominator of the given expression is: \[ 2 x y^{3} \cdot (2 x^{-3})^{4} \]
First, simplify \((2 x^{-3})^{4}\): \[ (2 x^{-3})^{4} = 2^{4} \cdot (x^{-3})^{4} = 16 x^{-12} \]
So, the denominator becomes: \[ 2 x y^{3} \cdot 16 x^{-12} = 32 x^{-11} y^{3} \]
Now, combine the simplified numerator and denominator: \[ \frac{2 x^{-3} y^{-3}}{32 x^{-11} y^{3}} \]
Simplify the fraction: \[ \frac{2}{32} \cdot \frac{x^{-3}}{x^{-11}} \cdot \frac{y^{-3}}{y^{3}} = \frac{1}{16} \cdot x^{8} \cdot y^{-6} \]
Thus, the simplified expression is: \[ \frac{x^{8}}{16 y^{6}} \]
\[ \boxed{\frac{x^{8}}{16 y^{6}}} \]
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