Questions: Question 5 In which way does alternative splicing of the Fibronectin gene illustrate the impact of splice site c A It leads to the generation of completely non-overlapping protein sequences. B It alters the length of introns in the final mRNA sequence. (C) It allows the formation of tissue-specific isoforms that differ in their cell adhesion propertie (D) It results in the skipping of exons that encode the protein's signal peptide. (E) it leads to exon retention that causes premature stop codons in all isoforms. Question 6 Which of the following is a consequence of promoter methylation on gene expression? A) Increased transcription factor binding (B) Silencing of gene expression (C) Increased gene expression (D) Enhancing RNA polymerase binding Last saved 3:01:07 PM Questions Filter (10)

Question 5

In which way does alternative splicing of the Fibronectin gene illustrate the impact of splice site c
A It leads to the generation of completely non-overlapping protein sequences.
B It alters the length of introns in the final mRNA sequence.
(C) It allows the formation of tissue-specific isoforms that differ in their cell adhesion propertie
(D) It results in the skipping of exons that encode the protein's signal peptide.
(E) it leads to exon retention that causes premature stop codons in all isoforms.

Question 6

Which of the following is a consequence of promoter methylation on gene expression?
A) Increased transcription factor binding
(B) Silencing of gene expression
(C) Increased gene expression
(D) Enhancing RNA polymerase binding

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Transcript text: Question 5 In which way does alternative splicing of the Fibronectin gene illustrate the impact of splice site c A It leads to the generation of completely non-overlapping protein sequences. B It alters the length of introns in the final mRNA sequence. (C) It allows the formation of tissue-specific isoforms that differ in their cell adhesion propertie (D) It results in the skipping of exons that encode the protein's signal peptide. (E) it leads to exon retention that causes premature stop codons in all isoforms. Question 6 Which of the following is a consequence of promoter methylation on gene expression? A) Increased transcription factor binding (B) Silencing of gene expression (C) Increased gene expression (D) Enhancing RNA polymerase binding Last saved 3:01:07 PM Questions Filter (10)

Solution

The answer to Question 5 is (C): It allows the formation of tissue-specific isoforms that differ in their cell adhesion properties.

Explanation:

(A) It leads to the generation of completely non-overlapping protein sequences: This is incorrect because alternative splicing typically results in proteins that share some common sequences but have different domains or regions.
(B) It alters the length of introns in the final mRNA sequence: This is incorrect because introns are spliced out and do not appear in the final mRNA sequence.
(C) It allows the formation of tissue-specific isoforms that differ in their cell adhesion properties: This is correct. Alternative splicing of the Fibronectin gene results in different isoforms that are expressed in a tissue-specific manner, affecting their cell adhesion properties.
(D) It results in the skipping of exons that encode the protein's signal peptide: This is incorrect because the skipping of exons can occur, but it is not specific to the signal peptide.
(E) It leads to exon retention that causes premature stop codons in all isoforms: This is incorrect because exon retention leading to premature stop codons is not a general feature of alternative splicing of the Fibronectin gene.

The answer to Question 6 is (B): Silencing of gene expression.

Explanation:

(A) Increased transcription factor binding: This is incorrect because promoter methylation typically reduces the binding of transcription factors.
(B) Silencing of gene expression: This is correct. Promoter methylation is a well-known mechanism for silencing gene expression by preventing the binding of transcription factors and other components necessary for transcription.
(C) Increased gene expression: This is incorrect because promoter methylation generally represses gene expression.
(D) Enhancing RNA polymerase binding: This is incorrect because promoter methylation usually inhibits the binding of RNA polymerase to the promoter region.

In summary: