To solve the given expression, we need to simplify it by combining like terms. This involves distributing any negative signs and then combining the coefficients of the same variable.
Step 1: Distribute the Negative Sign
First, distribute the negative sign in the second part of the expression:
\[
\left(-\frac{1}{8}c + 16\right) - \left(\frac{3}{8} + 3c\right) = -\frac{1}{8}c + 16 - \frac{3}{8} - 3c
\]
Step 2: Combine Like Terms
Next, combine the like terms. Combine the constant terms and the terms with \(c\):
\[
-\frac{1}{8}c - 3c + 16 - \frac{3}{8}
\]
Step 3: Simplify the Coefficients
Combine the coefficients of \(c\):
\[
-\frac{1}{8}c - 3c = -\frac{1}{8}c - \frac{24}{8}c = -\frac{25}{8}c
\]