To simplify the given expression, follow these steps:
First, simplify the expression inside the parentheses: \[ 6 + 2 = 8 \]
Next, multiply the result by 6: \[ 6 \times 8 = 48 \]
Then, multiply the result by 8: \[ 8 \times 48 = 384 \]
Calculate \(4^2\): \[ 4^2 = 16 \]
Finally, subtract the result from Step 3 from the result of Step 4: \[ 16 - 384 = -368 \]
\[ \boxed{-368} \]
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