Questions: Question 1 of 20 Which statement about acquired immunodeficiency syndrome (AIDS) is true? By definition all clients with HIV infection also have AIDS. Both B-cell and T-cell function are affected. B-cell function is unaffected. Heterosexual spread is the most common mode of spread in developed nations. SUBMIT ANSWER

The answer is the second one: Both B-cell and T-cell function are affected.

Explanation for each option:

1. By definition all clients with HIV infection also have AIDS.
   This statement is incorrect. Not all individuals with HIV infection have AIDS. HIV is the virus that causes AIDS, but a person can be HIV-positive for many years without developing AIDS. AIDS is the most advanced stage of HIV infection, characterized by a severely weakened immune system.

2. Both B-cell and T-cell function are affected.
   This statement is correct. HIV primarily targets CD4+ T-cells, which are crucial for immune function. As the disease progresses, the function of both T-cells and B-cells is compromised, leading to a weakened immune response.

3. B-cell function is unaffected.
   This statement is incorrect. While HIV primarily targets T-cells, B-cell function is also affected. The interaction between T-cells and B-cells is crucial for a healthy immune response, and the impairment of T-cells can lead to dysfunctional B-cell activity.

4. Heterosexual spread is the most common mode of spread in developed nations.
   This statement is incorrect. In many developed nations, the most common mode of HIV transmission is through male-to-male sexual contact. However, heterosexual transmission is a significant mode of spread in other parts of the world, particularly in developing countries.

In summary, the correct statement is that both B-cell and T-cell function are affected in individuals with AIDS.