To simplify the given expression, we need to distribute the constants and then combine like terms.
First, distribute the constant \(2\) across the terms inside the first parentheses: \[ 2(3x - 4y) = 6x - 8y \]
Next, distribute the negative sign across the terms inside the second parentheses: \[ -(x + 5y) = -x - 5y \]
Combine the like terms from the two expressions: \[ 6x - 8y - x - 5y \]
Combine the \(x\) terms: \[ 6x - x = 5x \]
Combine the \(y\) terms: \[ -8y - 5y = -13y \]
\(\boxed{5x - 13y}\)
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