Questions: Which treatment is considered a last resort for treating arthritis? Select one: weight loss and exercise, total joint replacement, MACl - matrix associated cartilage implantation, microfracture

The answer is the second one: total joint replacement.

Explanation for each option:

1. Weight loss and exercise: These are often recommended as initial treatments for arthritis. They can help reduce symptoms and improve joint function by decreasing stress on the joints and improving overall health. Therefore, they are not considered a last resort.

2. Total joint replacement: This is typically considered a last resort for treating arthritis, especially when other treatments have failed to relieve pain and improve function. It involves surgically replacing the damaged joint with an artificial one and is usually reserved for severe cases.

3. MACI - matrix associated cartilage implantation: This is a treatment option for cartilage damage, which can be associated with arthritis, but it is not typically considered a last resort. It is a more specialized procedure aimed at repairing cartilage defects.

4. Microfracture: This is a surgical technique used to treat cartilage damage by creating small fractures in the underlying bone to stimulate cartilage growth. It is not usually considered a last resort for arthritis treatment.

In summary, total joint replacement is considered a last resort treatment for arthritis when other less invasive treatments have not been successful.