Questions: Drag the labels to their appropriate locations to identify the type of point mutation shown.

Transcript text: Drag the labels to their appropriate locations to identify the type of point mutation shown.

Solution

Solution Steps

Step 1: Analyze the wild-type DNA

The wild-type DNA template strand is 3'-TACGCACCTACCATC-5'. Its corresponding mRNA is 5'-AUGCGUCCAUGCUAG-3', which translates to the amino acid sequence Met-Arg-His-Stop.

Step 2: Analyze the first mutation (C instead of A)

The mutated DNA template strand is 3'-TACGCCCCTACGATC-5'. The mRNA becomes 5'-AUGCGGCCAUGCUAG-3'. This translates to Met-Ala-His-Stop. This single nucleotide change results in a different amino acid being coded, therefore it is a missense mutation.

Step 3: Analyze the second mutation (T instead of G)

The mutated DNA template strand is 3'-TACGCAGGTACTATC-5'. The mRNA becomes 5'-AUGCGUCCAUGAUAG-3'. This translates to Met-Arg-His-Stop. Even though a nucleotide changed, the amino acid sequence remains the same. This is a silent mutation.

Final Answer:

Missense mutation
Silent mutation

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